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Has a currently accepted medical use in treatment in the United States.Abuse may lead to moderate or low physical dependence or high psychological dependence.Mood disorders and insomnia are often comorbid conditions, sharing a complex and bi-directional relationship. Kaynak H, Kaynak D, Gozukirmizi E, Guilleminault C. Complicating the situation, mood stabilizers can disrupt sleep in a variety of different ways depending on a drug’s mechanism of action, dosage level, and timing of administration. The effects of trazodone on sleep in patients treated with stimulant antidepressants.
These findings do not suggest that insomnia is merely part of a prodrome that occurs in close temporal association with affective disorders, as depression may first appear several years after the initial diagnosis of insomnia. QT prolongation and polymorphous ventricular tachycardia associated with trasodone-amiodarone combination.
In addition to these findings, it has been shown that insomnia is a precursor to the recurrence of depression in patients in remission, While insomnia often precedes the onset of affective illness, symptoms of depression and insomnia may be concurrent.
Complicating this picture is the fact that many antidepressants used to treat depression disturb sleep, potentially exacerbating the relationship between the two disorders.
The type of sleep disturbance produced by depression pharmacotherapy varies based on the compound’s mechanism of action and the dosage employed. Janowsky D, Curtis G, Zisook S, Kuhn K, Resovsky K, Le Winter M.
Effects may include decrements in rapid eye movement (REM) sleep, a lengthening of the time to sleep onset, and an increase in nocturnal arousals (Table 1). Ventricular arrhythmias possibly aggravated by trazodone.
A recent review50% for hypnotics, and were down approximately 25% for all forms of insomnia pharmacotherapy combined.